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Douglas R Higgs Selected Research

X-linked Nuclear Protein

1/2018How to Tackle Challenging ChIP-Seq, with Long-Range Cross-Linking, Using ATRX as an Example.
6/2011Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
7/2007Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.

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Douglas R Higgs Research Topics

Disease

16Thalassemia
01/2021 - 01/2004
8alpha-Thalassemia
05/2008 - 02/2002
7ATR-X syndrome
01/2022 - 02/2004
6Inborn Genetic Diseases (Disease, Hereditary)
01/2021 - 06/2003
5X-Linked Mental Retardation (Mental Retardation, X Linked)
01/2018 - 02/2005
4Anemia
06/2015 - 06/2003
3Hydrops Fetalis (Fetal Edema)
03/2024 - 01/2017
3Hemoglobinopathies
01/2016 - 01/2005
2Sickle Cell Anemia (Hemoglobin S Disease)
01/2016 - 06/2015
2Neoplasms (Cancer)
07/2015 - 01/2005
2Congenital Dyserythropoietic Anemia (Dyserythropoietic Anemia, Congenital)
09/2013 - 06/2011
2Intellectual Disability (Idiocy)
06/2011 - 10/2010
2beta-Thalassemia (Cooley's Anemia)
02/2008 - 05/2004
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
03/2004 - 02/2004
1Hypoxia (Hypoxemia)
03/2024
1Hemolysis
01/2017
1Hemolytic Anemia
03/2014
1Hypersensitivity (Allergy)
06/2013
1Starvation
08/2012
1Edema (Dropsy)
05/2010
1Confusion (Bewilderment)
01/2005
1Primary Myelofibrosis (Myelosclerosis)
01/2005
1Leukemia
02/2004

Drug/Important Bio-Agent (IBA)

19GlobinsIBA
03/2024 - 02/2002
13Proteins (Proteins, Gene)FDA Link
01/2018 - 02/2004
9ChromatinIBA
01/2022 - 03/2004
9alpha-GlobinsIBA
05/2010 - 06/2003
8Hemoglobins (Hemoglobin)IBA
11/2018 - 02/2002
3hemoglobin Bart'sIBA
11/2018 - 05/2010
3X-linked Nuclear ProteinIBA
01/2018 - 07/2007
2Histones (Histone)IBA
01/2018 - 06/2011
2Amino AcidsFDA Link
08/2012 - 03/2004
2HeterochromatinIBA
06/2011 - 02/2004
2beta-Globins (beta Globin)IBA
05/2004 - 01/2004
1NucleotidesIBA
01/2021
1Histone ChaperonesIBA
01/2018
1Histone DemethylasesIBA
01/2017
1DNA (Deoxyribonucleic Acid)IBA
07/2015
1Telomerase (Telomerase Reverse Transcriptase)IBA
07/2015
1Hemoglobin EIBA
06/2015
1erythroid Kruppel-like factorIBA
03/2014
1Transcription Factors (Transcription Factor)IBA
03/2014
1EndonucleasesIBA
09/2013
1Adenosine Triphosphate (ATP)IBA
09/2013
1Deoxyribonuclease I (Nickase)IBA
06/2013
1ElementsIBA
05/2006
1Core Binding Factors (Core-Binding Factor)IBA
01/2005
1Codon (Codons)IBA
03/2004
1ThymidineIBA
03/2004
1Hemoglobin HIBA
02/2004
1Protein Isoforms (Isoforms)IBA
02/2004
1Antisense RNA (Anti-Sense RNA)IBA
06/2003
1Hemoglobin Constant SpringIBA
02/2002
1Terminator Codon (Termination Codon)IBA
02/2002

Therapy/Procedure

2Therapeutics
01/2021 - 01/2017
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
06/2015
1Transcutaneous Electric Nerve Stimulation (TENS)
06/2015
1Blood Transfusion (Blood Transfusions)
03/2004